Trevor M Penning Selected Research

Polycyclic Aromatic Hydrocarbons (Polynuclear Aromatic Hydrocarbons)

6/2021	Environmental exposomics and lung cancer risk assessment in the Philadelphia metropolitan area using ZIP code-level hazard indices.
12/2017	Potential Metabolic Activation of Representative Alkylated Polycyclic Aromatic Hydrocarbons 1-Methylphenanthrene and 9-Ethylphenanthrene Associated with the Deepwater Horizon Oil Spill in Human Hepatoma (HepG2) Cells.
1/2017	Potential Metabolic Activation of a Representative C4-Alkylated Polycyclic Aromatic Hydrocarbon Retene (1-Methyl-7-isopropyl-phenanthrene) Associated with the Deepwater Horizon Oil Spill in Human Hepatoma (HepG2) Cells.
1/2017	Genotoxicity of ortho-quinones: reactive oxygen species versus covalent modification.
1/2016	Potential Metabolic Activation of a Representative C2-Alkylated Polycyclic Aromatic Hydrocarbon 6-Ethylchrysene Associated with the Deepwater Horizon Oil Spill in Human Hepatoma (HepG2) Cells.
11/2015	Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease.
10/2015	Metabolism of an Alkylated Polycyclic Aromatic Hydrocarbon 5-Methylchrysene in Human Hepatoma (HepG2) Cells.
5/2014	Metabolism of a representative oxygenated polycyclic aromatic hydrocarbon (PAH) phenanthrene-9,10-quinone in human hepatoma (HepG2) cells.
9/2012	Synthesis of 13C4-labelled oxidized metabolites of the carcinogenic polycyclic aromatic hydrocarbon benzo[a]pyrene.
5/2008	Evidence for the aldo-keto reductase pathway of polycyclic aromatic trans-dihydrodiol activation in human lung A549 cells.

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Trevor M Penning Research Topics

Disease

34	Neoplasms (Cancer) 01/2022 - 05/2004
32	Prostatic Neoplasms (Prostate Cancer) 01/2022 - 02/2003
12	Lung Neoplasms (Lung Cancer) 06/2021 - 06/2002
11	Breast Neoplasms (Breast Cancer) 01/2022 - 10/2002
11	Carcinogenesis 06/2021 - 03/2004
8	Hepatocellular Carcinoma (Hepatoma) 01/2019 - 03/2004
7	Carcinoma (Carcinomatosis) 02/2012 - 07/2002
4	Adenocarcinoma 01/2018 - 02/2003
4	Adenocarcinoma of Lung 05/2013 - 05/2008
3	Sudden Infant Death (SID) 01/2022 - 11/2013
3	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 11/2019 - 08/2016
3	Prostatic Hyperplasia (Benign Prostatic Hyperplasia) 07/2009 - 12/2006
2	Non-alcoholic Fatty Liver Disease 01/2022 - 10/2019
2	Polycystic Ovary Syndrome (Syndrome, Stein-Leventhal) 01/2022 - 01/2019
2	Endometrial Neoplasms (Endometrial Cancer) 11/2020 - 03/2006
2	Inflammation (Inflammations) 10/2019 - 05/2011
2	Neoplasm Metastasis (Metastasis) 01/2019 - 03/2006
2	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 01/2012 - 07/2002
2	Osteoporosis 03/2006 - 12/2004
1	Simpson-Golabi-Behmel syndrome 01/2022
1	Hyperandrogenism 01/2022
1	Body Weight (Weight, Body) 01/2022
1	Hypertriglyceridemia 01/2022
1	Endometriosis 01/2020
1	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 11/2019
1	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma (T-ALL) 11/2019
1	Leukemia 11/2019

Drug/Important Bio-Agent (IBA)

31	AndrogensIBA 01/2022 - 02/2003
17	Polycyclic Aromatic Hydrocarbons (Polynuclear Aromatic Hydrocarbons)IBA 06/2021 - 06/2002
16	Aldo-Keto ReductasesIBA 01/2021 - 07/2002
13	Hormones (Hormone)IBA 01/2022 - 03/2006
12	Androgen Receptors (Androgen Receptor)IBA 01/2021 - 02/2003
11	EnzymesIBA 01/2020 - 07/2002
9	SteroidsIBA 01/2022 - 01/2008
9	Estrogens (Estrogen)FDA Link 01/2021 - 03/2006
9	Testosterone (Sustanon)FDA Link 01/2020 - 03/2006
9	Pharmaceutical PreparationsIBA 11/2019 - 05/2004
7	Abiraterone AcetateIBA 01/2019 - 11/2014
6	Protein Isoforms (Isoforms)IBA 01/2020 - 07/2002
6	Proteins (Proteins, Gene)FDA Link 01/2020 - 03/2006
6	Hydroxysteroid DehydrogenasesIBA 01/2019 - 03/2006
6	Oxidoreductases (Dehydrogenase)IBA 01/2019 - 02/2003
6	Benzo(a)pyreneIBA 09/2012 - 03/2007
5	CarcinogensIBA 01/2022 - 06/2002
5	ProstaglandinsIBA 01/2020 - 01/2005
5	Biological ProductsIBA 11/2019 - 11/2006
5	LigandsIBA 01/2019 - 01/2005
5	prostaglandin-F synthaseIBA 01/2019 - 01/2008
4	IsotopesIBA 01/2022 - 11/2013
4	Messenger RNA (mRNA)IBA 01/2020 - 03/2004
4	enzalutamideIBA 01/2019 - 01/2016
4	QuinonesIBA 01/2017 - 03/2004
4	quinone (benzoquinone)IBA 01/2017 - 05/2008
4	DNA (Deoxyribonucleic Acid)IBA 12/2013 - 01/2006
4	trans-1,2-dihydro-1,2-naphthalenediolIBA 11/2008 - 07/2002
3	SmokeIBA 01/2016 - 06/2002
3	IsoenzymesIBA 01/2012 - 10/2002
2	Transcription Factors (Transcription Factor)IBA 01/2022 - 09/2009
2	Triglycerides (Triacylglycerol)IBA 01/2022 - 10/2019
2	Insulin (Novolin)FDA Link 01/2022 - 01/2022
2	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2021 - 12/2011
2	Progesterone FDA LinkGeneric 01/2020 - 03/2006
2	Daunorubicin (Cerubidine)FDA LinkGeneric 11/2019 - 08/2016
2	Glucocorticoid Receptors (Glucocorticoid Receptor)IBA 01/2019 - 01/2019
2	Aromatase (CYP19)IBA 01/2019 - 03/2009
2	DNA AdductsIBA 11/2018 - 05/2013
2	Dihydrotestosterone (Androstanolone)IBA 12/2017 - 03/2006
2	Leuprolide (Lupron)FDA LinkGeneric 01/2017 - 11/2014
2	NADP (NADPH)IBA 11/2015 - 05/2008
2	Bile Acids and Salts (Bile Acids)IBA 10/2015 - 06/2015
2	Tretinoin (Retinoic Acid)FDA LinkGeneric 06/2015 - 11/2008
2	Indomethacin (Indometacin)FDA LinkGeneric 03/2013 - 01/2008
2	8-Hydroxy-2'-DeoxyguanosineIBA 12/2011 - 11/2006
2	Estrone FDA Link 05/2011 - 08/2010
2	3 (or 17)-beta-hydroxysteroid dehydrogenaseIBA 07/2010 - 03/2009
2	Prostaglandins DIBA 02/2010 - 01/2005
2	tiboloneIBA 03/2006 - 12/2004
2	ResveratrolIBA 11/2004 - 05/2004
1	Pregnane X ReceptorIBA 01/2022
1	DioxinsIBA 01/2022
1	Aromatase InhibitorsIBA 01/2022
1	Glucose (Dextrose)FDA LinkGeneric 01/2022
1	exemestane (Aromasin)FDA Link 01/2022
1	LipidsIBA 01/2022
1	perfluorooctanoic acidIBA 01/2022
1	PesticidesIBA 01/2022
1	Vehicle Emissions (Emissions, Vehicle)IBA 06/2021
1	Air Pollutants (Pollutants, Air)IBA 06/2021
1	Volatile Organic CompoundsIBA 06/2021
1	Progestins (Progestagens)IBA 01/2021
1	Lipid PeroxidesIBA 01/2021
1	Gonadal Steroid Hormones (Sex Hormones)IBA 01/2020
1	BAY1128688IBA 01/2020
1	Cytarabine (Cytosar-U)FDA LinkGeneric 11/2019
1	AnthracyclinesIBA 11/2019

Therapy/Procedure

19	Castration 01/2021 - 05/2010
13	Therapeutics 01/2021 - 03/2006
3	Prostatectomy (Retropubic Prostatectomy) 01/2017 - 11/2014
2	Drug Therapy (Chemotherapy) 01/2017 - 08/2016
1	Drug Tapering 11/2019